| http://purl.uniprot.org/citations/24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24224652 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-12 (IL-12) p70 and IL-23 are bioactive cytokines and their biological functions are becoming clear. Increased expression of IL-7 in the central nervous system as well as in peripheral immune cells is associated with multiple sclerosis and experimental allergic encephalomyelitis. Here, we describe the induction of IL-7 in primary mouse and human microglia, BV-2 microglial cells, mouse peritoneal macrophages and astrocytes by IL-12p70. Interestingly, IL-12 strongly induced the expression of IL-7 whereas IL-23 and other p40 family members remained weak inducers of IL-7 in these cell types. Consistently, IL-12, but not IL-23 and other p40 family members, induced IL-7 promoter-driven luciferase activity in microglial cells. Among various stimuli tested, IL-12 emerged as the most potent stimulus followed by bacterial lipopolysaccharide and HIV-1 gp120 in inducing the activation of IL-7 promoter in microglial cells. Furthermore, increase in IL-7 mRNA expression by over-expression of IL-12p35 subunit, but not p40 and IL-23 p19 subunit, confirm that p35, but not p40 and p19, is responsible for the induction of IL-7. Finally, by using primary microglia from IL-12 receptor β1-deficient (IL-12Rβ1(-/-)) and IL-12Rβ2(-/-) mice, we demonstrate that IL-12 induces the expression of IL-7 in microglia and macrophages via both IL-12Rβ2 and IL-12Rβ1. These studies delineate a novel biological function of IL-12 that is absent in IL-23 and other p40 family members."xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.org/dc/terms/identifier | "doi:10.1111/imm.12214"xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/author | "Mondal S."xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/author | "Jana A."xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/author | "Jana M."xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/author | "Pahan K."xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/pages | "549-563"xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/title | "Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/24224652 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24224652 |
| http://purl.uniprot.org/citations/24224652 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24224652 |
| http://purl.uniprot.org/uniprot/#_D0EYG7-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTG5-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RL98-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLC9-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_A8K673-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_D3Z6H5-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_F8WI71-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_P13232-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_P10168-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_Q3UT18-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |
| http://purl.uniprot.org/uniprot/#_Q3ZAX5-mappedCitation-24224652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24224652 |