| http://purl.uniprot.org/citations/24225024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24225024 | http://www.w3.org/2000/01/rdf-schema#comment | "The HIV-1 viral infectivity factor (Vif) neutralizes cell-encoded antiviral APOBEC3 proteins by recruiting a cellular ElonginB (EloB)/ElonginC (EloC)/Cullin5-containing ubiquitin ligase complex, resulting in APOBEC3 ubiquitination and proteolysis. The suppressors-of-cytokine-signalling-like domain (SOCS-box) of HIV-1 Vif is essential for E3 ligase engagement, and contains a BC box as well as an unusual proline-rich motif. Here, we report the NMR solution structure of the Vif SOCS-ElonginBC (EloBC) complex. In contrast to SOCS-boxes described in other proteins, the HIV-1 Vif SOCS-box contains only one α-helical domain followed by a β-sheet fold. The SOCS-box of Vif binds primarily to EloC by hydrophobic interactions. The functionally essential proline-rich motif mediates a direct but weak interaction with residues 101-104 of EloB, inducing a conformational change from an unstructured state to a structured state. The structure of the complex and biophysical studies provide detailed insight into the function of Vif's proline-rich motif and reveal novel dynamic information on the Vif-EloBC interaction."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.130100"xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Malim M.H."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Atkinson R.A."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Matthews S.J."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Sanderson M.R."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Bergeron J.R."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Schaller T."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Veselkov D.A."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/author | "Oregioni A."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/name | "Open Biol"xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/pages | "130100"xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/title | "Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction."xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/24225024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24225024 |
| http://purl.uniprot.org/citations/24225024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24225024 |
| http://purl.uniprot.org/uniprot/#_A0A288CG30-mappedCitation-24225024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24225024 |
| http://purl.uniprot.org/uniprot/#_Q15369-mappedCitation-24225024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24225024 |
| http://purl.uniprot.org/uniprot/#_Q15370-mappedCitation-24225024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24225024 |
| http://purl.uniprot.org/uniprot/#_P12504-mappedCitation-24225024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24225024 |
| http://purl.uniprot.org/uniprot/#_P69720-mappedCitation-24225024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24225024 |