| http://purl.uniprot.org/citations/24225442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24225442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24225442 | http://www.w3.org/2000/01/rdf-schema#comment | "During apoptosis, phosphatidylserine (PS), normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and serves as an 'eat-me' signal to trigger phagocytosis. It is poorly understood how PS exposure is activated in apoptotic cells. Here we report that CED-8, a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis and a homologue of the XK family proteins, is a substrate of the CED-3 caspase. Cleavage of CED-8 by CED-3 activates its proapoptotic function and generates a carboxyl-terminal cleavage product, acCED-8, that promotes PS externalization in apoptotic cells and can induce ectopic PS exposure in living cells. Consistent with its role in promoting PS externalization in apoptotic cells, ced-8 is important for cell corpse engulfment in C. elegans. Our finding identifies a crucial link between caspase activation and PS externalization, which triggers phagocytosis of apoptotic cells."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3726"xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3726"xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Chen Y.Z."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Chen Y.Z."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Lee E.S."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Lee E.S."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Mapes J."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Mapes J."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Skeen-Gaar R.R."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/author | "Skeen-Gaar R.R."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/pages | "2726"xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/pages | "2726"xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/title | "Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/title | "Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization."xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24225442 | http://purl.uniprot.org/core/volume | "4"xsd:string |