| http://purl.uniprot.org/citations/24225951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24225951 | http://www.w3.org/2000/01/rdf-schema#comment | "Widely expressed in the adult central nervous system, the cellular prion protein (PrP(C)) is implicated in a variety of processes, including neuronal excitability. Dipeptidyl aminopeptidase-like protein 6 (DPP6) was first identified as a PrP(C) interactor using in vivo formaldehyde cross-linking of wild type (WT) mouse brain. This finding was confirmed in three cell lines and, because DPP6 directs the functional assembly of K(+) channels, we assessed the impact of WT and mutant PrP(C) upon Kv4.2-based cell surface macromolecular complexes. Whereas a Gerstmann-Sträussler-Scheinker disease version of PrP with eight extra octarepeats was a loss of function both for complex formation and for modulation of Kv4.2 channels, WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude, a rightward shift of the voltage-dependent steady-state inactivation curve, a slower inactivation, and a faster recovery from steady-state inactivation. Thus, the net impact of wt PrP(C) was one of enhancement, which plays a critical role in the down-regulation of neuronal membrane excitability and is associated with a decreased susceptibility to seizures. Insofar as previous work has established a requirement for WT PrP(C) in the Aβ-dependent modulation of excitability in cholinergic basal forebrain neurons, our findings implicate PrP(C) regulation of Kv4.2 channels as a mechanism contributing to the effects of oligomeric Aβ upon neuronal excitability and viability."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.488650"xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Coulthart M.B."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Wohlgemuth S."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Schmitt-Ulms G."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Cashman N.R."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Westaway D."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Strome R."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Watts J.C."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Mercer R.C."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/author | "Jhamandas J.H."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/pages | "37241-37255"xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/title | "The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6."xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/24225951 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24225951 |
| http://purl.uniprot.org/citations/24225951 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24225951 |
| http://purl.uniprot.org/uniprot/Q9Z218#attribution-2DFF8E792E3653EF5CD18D2C3F58F2FD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24225951 |
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| http://purl.uniprot.org/uniprot/P04925#attribution-4AA023DCAB5475F3504D8C0DA11D4DD3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24225951 |
| http://purl.uniprot.org/uniprot/#_D4P3Q7-mappedCitation-24225951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24225951 |