| http://purl.uniprot.org/citations/24227884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24227884 | http://www.w3.org/2000/01/rdf-schema#comment | "Homotypic membrane tethering by the Golgi reassembly and stacking proteins (GRASPs) is required for the lateral linkage of mammalian Golgi ministacks into a ribbon-like membrane network. Although GRASP65 and GRASP55 are specifically localized to cis and medial/trans cisternae, respectively, it is unknown whether each GRASP mediates cisternae-specific tethering and whether such specificity is necessary for Golgi compartmentalization. Here each GRASP was tagged with KillerRed (KR), expressed in HeLa cells, and inhibited by 1-min exposure to light. Significantly, inactivation of either GRASP unlinked the Golgi ribbon, and the immediate effect of GRASP65-KR inactivation was a loss of cis-rather than trans-Golgi integrity, whereas inactivation of GRASP55-KR first affected the trans- and not the cis-Golgi. Thus each GRASP appears to play a direct and cisternae-specific role in linking ministacks into a continuous membrane network. To test the consequence of loss of cisternae-specific tethering, we generated Golgi membranes with a single GRASP on all cisternae. Remarkably, the membranes exhibited the full connectivity of wild-type Golgi ribbons but were decompartmentalized and defective in glycan processing. Thus the GRASP isoforms specifically link analogous cisternae to ensure Golgi compartmentalization and proper processing."xsd:string |
| http://purl.uniprot.org/citations/24227884 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-07-0395"xsd:string |
| http://purl.uniprot.org/citations/24227884 | http://purl.uniprot.org/core/author | "Linstedt A.D."xsd:string |
| http://purl.uniprot.org/citations/24227884 | http://purl.uniprot.org/core/author | "Jarvela T."xsd:string |
| http://purl.uniprot.org/citations/24227884 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24227884 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/24227884 | http://purl.uniprot.org/core/pages | "133-144"xsd:string |
| http://purl.uniprot.org/citations/24227884 | http://purl.uniprot.org/core/title | "Isoform-specific tethering links the Golgi ribbon to maintain compartmentalization."xsd:string |
| http://purl.uniprot.org/citations/24227884 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B4DNR1-mappedCitation-24227884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24227884 |
| http://purl.uniprot.org/uniprot/#_B3KPY8-mappedCitation-24227884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24227884 |
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