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| http://purl.uniprot.org/citations/24228869 | http://www.w3.org/2000/01/rdf-schema#comment | "In Drosophila melanogaster M. (Diptera: Drosophilidae), a phospholipase-C to proteininase-C signal cascade leads to the endocytic uptake of yolk precursor molecules. The data suggest that D. melanogaster has a phospholipase-C/proteinkinase-C signaling pathway similar to that previously shown to be required for vitellogenesis in the milkweed bug, Oncopeltus fasciatus Dallas (Hemiptera: Lygaeidae). Calmodulin, derived from epithelial cells and transported to the oocytes via gap junctions, may trigger this pathway. To investigate this, a series of known antagonists to various elements of the pathway were used. W-7 (which prevents calmodulin binding to phospholipase-C), U-73122 (which prevents activation of phospholipase-C), verapamil (which blocks Ca(2+) release by IP3), HAG (which blocks diacylglycerol), and staurosporine (which inactivates proteinkinase-C) were each shown to inhibit endocytosis, thereby blocking formation of nascent yolk spheres."xsd:string |
| http://purl.uniprot.org/citations/24228869 | http://purl.org/dc/terms/identifier | "doi:10.1673/031.013.6801"xsd:string |
| http://purl.uniprot.org/citations/24228869 | http://purl.uniprot.org/core/author | "Brubaker-Purkey B.J."xsd:string |
| http://purl.uniprot.org/citations/24228869 | http://purl.uniprot.org/core/author | "Woodruff R.I."xsd:string |
| http://purl.uniprot.org/citations/24228869 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24228869 | http://purl.uniprot.org/core/name | "J Insect Sci"xsd:string |
| http://purl.uniprot.org/citations/24228869 | http://purl.uniprot.org/core/pages | "68"xsd:string |
| http://purl.uniprot.org/citations/24228869 | http://purl.uniprot.org/core/title | "Vitellogenesis in the fruit fly, Drosophila melanogaster: antagonists demonstrate that the PLC, IP3/DAG, PK-C pathway is triggered by calmodulin."xsd:string |
| http://purl.uniprot.org/citations/24228869 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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