DESCRIBE <http://purl.uniprot.org/citations/24232815>

Subject	Predicate	Object
http://purl.uniprot.org/citations/24232815	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24232815	http://www.w3.org/2000/01/rdf-schema#comment	" Objective The aim of the present study was investigate the association between six genetic variants in the nuclear receptor genes PPARA, RXRA, NR1I2 and NR1I3 and the lipid-lowering efficacy and safety of statin therapy. Subjects and methods The study was carried out on 240 Brazilian hypercholesterolemic patients on simvastatin and atorvastatin therapy. The polymorphisms were analyzed by PCR-based methods. Results The NR1I3 rs2307424 genotype distribution was different between subjects with and without adverse drug reactions. Among subjects in the ADR group, no T/T homozygotes were observed for this polymorphism, while in the non-ADR group the frequency of this genotype was 19.4% (P = 0.007, after multiple testing corrections P = 0.042). Conclusion The polymorphisms investigated in PPARA (rs1800206), RXRA (rs11381416), and NR1I2 (rs1523130) did not influence the lipid-lowering efficacy and safety of statin. Our results show the possible influence of NR1I3 genetic variant on the safety of statin."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.org/dc/terms/identifier	"doi:10.1590/s0004-27302013000700003"xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Ferreira M.E."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Almeida S."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Pires R.C."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Hutz M.H."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Fiegenbaum M."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Van der Sand C.R."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Van der Sand L.C."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Lima L.O."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/author	"Bruxel E.M."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/date	"2013"xsd:gYear
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/name	"Arq Bras Endocrinol Metabol"xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/pages	"513-519"xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/title	"Influence of PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms on the lipid-lowering efficacy and safety of statin therapy."xsd:string
http://purl.uniprot.org/citations/24232815	http://purl.uniprot.org/core/volume	"57"xsd:string
http://purl.uniprot.org/citations/24232815	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/24232815
http://purl.uniprot.org/citations/24232815	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/24232815
http://purl.uniprot.org/uniprot/#_A0A5F9ZHH6-mappedCitation-24232815	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24232815
http://purl.uniprot.org/uniprot/#_C0H5Y2-mappedCitation-24232815	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24232815
http://purl.uniprot.org/uniprot/#_B3KVM5-mappedCitation-24232815	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24232815
http://purl.uniprot.org/uniprot/#_B6ZGT1-mappedCitation-24232815	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24232815
http://purl.uniprot.org/uniprot/#_B6ZGT2-mappedCitation-24232815	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24232815
http://purl.uniprot.org/uniprot/#_B7Z8Q3-mappedCitation-24232815	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24232815