| http://purl.uniprot.org/citations/24235147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24235147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24235147 | http://www.w3.org/2000/01/rdf-schema#comment | "Circadian rhythm is a biological rhythm governing physiology and behavior with a period of ∼24 h. At the molecular level, circadian output is controlled by a molecular clock composed of positive and negative feedback loops in transcriptional and post-translational processes. CLOCK is a transcription factor known as a central component of the molecular clock feedback loops generating circadian oscillation. Although CLOCK is known to undergo multiple post-translational modifications, the knowledge of their entities remains limited. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase that is involved in various neuronal processes. Here, we report that Cdk5 is a novel regulator of CLOCK protein. Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. The Cdk5-dependent regulation of CLOCK function is mediated by alterations of its stability and subcellular distribution. These results suggest that Cdk5 is a novel regulatory component of the core molecular clock machinery."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.494856"xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.494856"xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Park S.K."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Park S.K."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Cho S."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Cho S."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Mikoshiba K."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Mikoshiba K."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Jeong J."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Jeong J."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Kwak Y."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Kwak Y."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Lee S.A."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Lee S.A."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Han D.H."xsd:string |
| http://purl.uniprot.org/citations/24235147 | http://purl.uniprot.org/core/author | "Han D.H."xsd:string |