| http://purl.uniprot.org/citations/24238340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24238340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24238340 | http://www.w3.org/2000/01/rdf-schema#comment | "The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-independent role for ATG16L1 in negatively regulating Nod-driven inflammatory responses. Knockdown of ATG16L1 expression, but not that of ATG5 or ATG9a, specifically enhanced Nod-driven cytokine production. In addition, autophagy-incompetent truncated forms of ATG16L1 regulated Nod-driven cytokine responses. Mechanistically, we demonstrated that ATG16L1 interfered with poly-ubiquitination of the Rip2 adaptor and recruitment of Rip2 into large signaling complexes. The CD-associated allele of ATG16L1 was impaired in its ability to regulate Nod-driven inflammatory responses. Overall, these results suggest that ATG16L1 is critical for Nod-dependent regulation of cytokine responses and that disruption of this Nod1- or Nod2-ATG16L1 signaling axis could contribute to the chronic inflammation associated with CD."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2013.10.013"xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2013.10.013"xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Ellison L.K."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Ellison L.K."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Girardin S.E."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Girardin S.E."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Jones N.L."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Jones N.L."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Philpott D.J."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Philpott D.J."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Ramjeet M."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Ramjeet M."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Sorbara M.T."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Sorbara M.T."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Travassos L.H."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/author | "Travassos L.H."xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/pages | "858-873"xsd:string |
| http://purl.uniprot.org/citations/24238340 | http://purl.uniprot.org/core/pages | "858-873"xsd:string |