| http://purl.uniprot.org/citations/24239348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24239348 | http://www.w3.org/2000/01/rdf-schema#comment | "A fundamental limitation in devising new therapeutic strategies for killing cancer cells with DNA damaging agents is the need to identify synthetic lethal interactions between tumor-specific mutations and components of the DNA damage response (DDR) in vivo. The stress-activated p38 mitogen-activated protein kinase (MAPK)/MAPKAP kinase-2 (MK2) pathway is a critical component of the DDR network in p53-deficient tumor cells in vitro. To explore the relevance of this pathway for cancer therapy in vivo, we developed a specific gene targeting strategy in which Cre-mediated recombination simultaneously creates isogenic MK2-proficient and MK2-deficient tumors within a single animal. This allows direct identification of MK2 synthetic lethality with mutations that promote tumor development or control response to genotoxic treatment. In an autochthonous model of non-small-cell lung cancer (NSCLC), we demonstrate that MK2 is responsible for resistance of p53-deficient tumors to cisplatin, indicating synthetic lethality between p53 and MK2 can successfully be exploited for enhanced sensitization of tumors to DNA-damaging chemotherapeutics in vivo."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2013.10.025"xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Kim J.S."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Jacks T."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Reinhardt H.C."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Cannell I.G."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Morandell S."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Mitra T."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Couvillon A.D."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/author | "Ruf D.M."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/pages | "868-877"xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/title | "A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo."xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24239348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24239348 |
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| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-24239348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239348 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P7V9-mappedCitation-24239348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239348 |