| http://purl.uniprot.org/citations/24239353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24239353 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of the human Parkinson-disease-associated protein α-synuclein in all Drosophila neurons induces progressive locomotor deficits. Here, we identify a group of 15 dopaminergic neurons per hemisphere in the anterior medial region of the brain whose disruption correlates with climbing impairments in this model. These neurons selectively innervate the horizontal β and β' lobes of the mushroom bodies, and their connections to the Kenyon cells are markedly reduced when they express α-synuclein. Using selective mushroom body drivers, we show that blocking or overstimulating neuronal activity in the β' lobe, but not the β or γ lobes, significantly inhibits negative geotaxis behavior. This suggests that modulation of the mushroom body β' lobes by this dopaminergic pathway is specifically required for an efficient control of startle-induced locomotion in flies."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2013.10.032"xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Jacquet M."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Nguyen M.V."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Fiala A."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Pech U."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Birman S."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Cassar M."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Riemensperger T."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Coulom H."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/author | "Issa A.R."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/pages | "952-960"xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/title | "A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease."xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24239353 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24239353 |
| http://purl.uniprot.org/citations/24239353 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24239353 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFI1-mappedCitation-24239353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239353 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEP4-mappedCitation-24239353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239353 |
| http://purl.uniprot.org/uniprot/#_A0A6M3Q705-mappedCitation-24239353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239353 |
| http://purl.uniprot.org/uniprot/#_A0A6M3Q797-mappedCitation-24239353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239353 |
| http://purl.uniprot.org/uniprot/#_A0A6M3Q823-mappedCitation-24239353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239353 |
| http://purl.uniprot.org/uniprot/#_A0A6M3QA49-mappedCitation-24239353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24239353 |