| http://purl.uniprot.org/citations/24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24240235 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this instability is mediated by cotranscriptional R loops, which are believed to increase by suboptimal assembly of the nascent messenger ribonucleoprotein particle (mRNP). However, no clear evidence exists that heterogeneous nuclear RNPs (hnRNPs), the basic mRNP components, prevent R-loop stabilization. Here we show that yeast Npl3, the most abundant RNA-binding hnRNP, prevents R-loop-mediated genome instability. npl3Δ cells show transcription-dependent and R-loop-dependent hyperrecombination and genome-wide replication obstacles as determined by accumulation of the Rrm3 helicase. Such obstacles preferentially occur at long and highly expressed genes, to which Npl3 is preferentially bound in wild-type cells, and are reduced by RNase H1 overexpression. The resulting replication stress confers hypersensitivity to double-strand break-inducing agents. Therefore, our work demonstrates that mRNP factors are critical for genome integrity and opens the option of using them as therapeutic targets in anti-cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.229880.113"xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/author | "Moreno S."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/author | "Garcia-Rubio M.L."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/author | "Marin A."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/author | "Herrero A.B."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/author | "Santos-Pereira J.M."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/pages | "2445-2458"xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/title | "The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability."xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/24240235 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24240235 |
| http://purl.uniprot.org/citations/24240235 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24240235 |
| http://purl.uniprot.org/uniprot/#_A0A6A5PYH5-mappedCitation-24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/#_P40040-mappedCitation-24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/#_Q04740-mappedCitation-24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/#_P32505-mappedCitation-24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/#_Q07478-mappedCitation-24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/#_P38766-mappedCitation-24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/#_Q01560-mappedCitation-24240235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/Q04740 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24240235 |
| http://purl.uniprot.org/uniprot/P38766 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24240235 |