| http://purl.uniprot.org/citations/24240590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24240590 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify novel biomarkers for the diagnosis and prognosis of human primary lung squamous cell carcinoma (SCC), we compared the spectrum of proteins expressed in SCC and in the adjacent non-cancer tissue, using QSTAR Elite liquid chromatography with tandem mass spectrometry (LC-MS/MS), coupled with iTRAQ technology. We identified 410 proteins differentially expressed in more than 75% of patients, and validated the expression of candidate target proteins by immunohistochemistry. Based on the results of LC-MS/MS, Ingenuity Pathway Analysis and immunohistochemical analyses, myristoylated alanine-rich C-kinase substrate (MARCKS) (upregulated 2.28-fold, p< 0.005) was selected as a potential biomarker of human lung SCC. In order to evaluate the association between patient prognosis and the expression of candidate biomarkers, univariate survival analysis was performed with disease-specific survival curves according to the Kaplan-Meier method, and differences in survival were assessed with the log-rank test. Immunohistochemical evaluation of MARCKS in 99 patients with lung SCC revealed a significant association between positive expression and poor prognosis compared with patients with negative expression (log-rank test; p=0.024). These results indicate that MARCKS may represent a potential biomarker for the prognosis of primary lung SCC."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.org/dc/terms/identifier | "doi:10.3233/cbm-130354"xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Inoue H."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Hanada S."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Komatsu H."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Yamano S."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Wei M."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Chung K."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Nishiyama N."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Suehiro S."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Wanibuchi H."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/author | "Kakehashi A."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/name | "Cancer Biomark"xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/pages | "289-298"xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/title | "Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/24240590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24240590 |
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| http://purl.uniprot.org/uniprot/#_P29966-mappedCitation-24240590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24240590 |
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| http://purl.uniprot.org/uniprot/P29966 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24240590 |
| http://purl.uniprot.org/uniprot/Q6NVI1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24240590 |