| http://purl.uniprot.org/citations/24243019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24243019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24243019 | http://www.w3.org/2000/01/rdf-schema#comment | "Direct lineage reprogramming is a promising approach for human disease modeling and regenerative medicine, with poorly understood mechanisms. Here, we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1, Brn2, and Myt1l. Ascl1 acts as an "on-target" pioneer factor by immediately occupying most cognate genomic sites in fibroblasts. In contrast, Brn2 and Myt1l do not access fibroblast chromatin productively on their own; instead, Ascl1 recruits Brn2 to Ascl1 sites genome wide. A unique trivalent chromatin signature in the host cells predicts the permissiveness for Ascl1 pioneering activity among different cell types. Finally, we identified Zfp238 as a key Ascl1 target gene that can partially substitute for Ascl1 during iN cell reprogramming. Thus, a precise match between pioneer factors and the chromatin context at key target genes is determinative for transdifferentiation to neurons and likely other cell types."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.09.028"xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.09.028"xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Brunet A."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Brunet A."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Chang H.Y."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Chang H.Y."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Drechsel D."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Drechsel D."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Qu K."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Qu K."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Wernig M."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Wernig M."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Vierbuchen T."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Vierbuchen T."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Castro D.S."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Castro D.S."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Chanda S."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Chanda S."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Fuentes D.R."xsd:string |
| http://purl.uniprot.org/citations/24243019 | http://purl.uniprot.org/core/author | "Fuentes D.R."xsd:string |