| http://purl.uniprot.org/citations/24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24244486 | http://www.w3.org/2000/01/rdf-schema#comment | "ICK/MRK (intestinal cell kinase/MAK-related kinase), MAK (male germ cell-associated kinase), and MOK (MAPK/MAK/MRK-overlapping kinase) are closely related serine/threonine protein kinases in the protein kinome. The biological functions and regulatory mechanisms of the ICK/MAK/MOK family are still largely elusive. Despite significant similarities in their catalytic domains, they diverge markedly in the sequence and structural organization of their C-terminal non-catalytic domains, raising the question as to whether they have distinct, overlapping, or redundant biological functions. In order to gain insights into their biological activities and lay a fundamental groundwork for functional studies, we investigated the spatio-temporal distribution patterns and the expression dynamics of ICK/MAK/MOK protein kinases in the intestine. We found that ICK/MAK/MOK proteins display divergent expression patterns along the duodenum-to-colon axis and during postnatal murine development. Furthermore, they are differentially partitioned between intestinal epithelium and mesenchyme. A significant increase in the protein level of ICK, but not MAK, was induced in human primary colon cancer specimens. ICK protein level was up-regulated whereas MOK protein level was down-regulated in mouse intestinal adenomas as compared with their adjacent normal intestinal mucosa. These data suggest distinct roles for ICK/MAK/MOK protein kinases in the regulation of intestinal neoplasia. Taken together, our findings demonstrate that the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases."xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0079359"xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/author | "Moskaluk C.A."xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/pages | "e79359"xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/title | "Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity."xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24244486 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24244486 |
| http://purl.uniprot.org/citations/24244486 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24244486 |
| http://purl.uniprot.org/uniprot/#_A0A286YD80-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_A0A140VK28-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_B3KUS6-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_F8VBW7-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_Q3UZZ3-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_Q04859-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_Q8IXN4-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_P20794-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_Q5M8P5-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_Q3U4K6-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |
| http://purl.uniprot.org/uniprot/#_Q49A77-mappedCitation-24244486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244486 |