| http://purl.uniprot.org/citations/24244850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24244850 | http://www.w3.org/2000/01/rdf-schema#comment | "The primary cilium is an essential organelle required for animal development and adult homeostasis that is found on most animal cells. The primary cilium contains a microtubule-based axoneme cytoskeleton that typically grows from the mother centriole in G0/G1 phase of the cell cycle as a membrane-bound compartment that protrudes from the cell surface. A unique system of bidirectional transport, intraflagellar transport (IFT), maintains the structure and function of cilia. While the axoneme is dynamic, growing and shrinking at its tip, at the same time it is very stable to the effects of microtubule-targeting drugs. The primary cilia found on Drosophila spermatocytes diverge from the general rules of primary cilium biology in several respects. Among these unique attributes, spermatocyte cilia assemble from all four centrioles in an IFT-independent manner in G2 phase, and persist continuously through two cell divisions. Here, we show that Drosophila spermatocyte primary cilia are extremely sensitive to microtubule-targeting drugs, unlike their mammalian counterparts. Spermatocyte cilia and their axonemes fail to assemble or be maintained upon nocodazole treatment, while centriole replication appears unperturbed. On the other hand, paclitaxel (Taxol), a microtubule-stabilizing drug, disrupted transition zone assembly and anchoring to the plasma membrane while causing spermatocyte primary cilia to grow extensively long during the assembly/elongation phase, but did not overtly affect the centrioles. However, once assembled to their mature length, spermatocyte cilia appeared unaffected by Taxol. The effects of these drugs on axoneme dynamics further demonstrate that spermatocyte primary cilia are endowed with unique assembly properties."xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.org/dc/terms/identifier | "doi:10.1242/bio.20135355"xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/author | "Megraw T.L."xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/author | "Callaini G."xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/author | "Riparbelli M.G."xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/author | "Cabrera O.A."xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/name | "Biol Open"xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/pages | "1137-1147"xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/title | "Unique properties of Drosophila spermatocyte primary cilia."xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/24244850 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24244850 |
| http://purl.uniprot.org/citations/24244850 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24244850 |
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| http://purl.uniprot.org/uniprot/#_Q9VRF2-mappedCitation-24244850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24244850 |
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