DESCRIBE <http://purl.uniprot.org/citations/24245748>

Subject	Predicate	Object
http://purl.uniprot.org/citations/24245748	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24245748	http://www.w3.org/2000/01/rdf-schema#comment	" Rationale Club (Clara) cell protein 16 (CC-16) is a protein that is synthesized predominantly in the lungs and is detectable in serum. Its expression decreases with lung injury and smoking, and is thus a marker of bronchial cell dysfunction. Objectives To evaluate the possibility of using serum CC-16 as a biomarker for disease progression in chronic obstructive pulmonary disease (COPD). Methods We measured serum CC-16 levels from 4,724 subjects with mild-to-moderate airflow limitation in the Lung Health Study. Using a linear regression model, we determined the relationship of serum CC-16 concentrations to decline in lung function over 9 years. In addition, to determine whether CC-16 plays a major role in the pathogenesis of mild COPD, we exposed CC-16-deficient (-/-) mice to 6 months of cigarette smoke. Measurements and main results Reduced serum concentrations of CC-16 were associated with accelerated decline in FEV1 over 9 years (P < 0.0001), and this association persisted after adjustments for age, sex, race, smoking status, airway reactivity, body mass index, and baseline FEV1 (P = 0.0002). However, CC-16(-/-) mice did not demonstrate an enhanced risk of emphysema or small airway remodeling in response to cigarette smoke. Conclusions Serum CC-16 is associated with disease progression, and may assist in the identification of "rapid progressors." However, the absence of CC-16 does not appear to modify the risk of cigarette-related COPD in mice."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.org/dc/terms/identifier	"doi:10.1164/rccm.201305-0892oc"xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Li Y."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Park H.Y."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Tam S."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Wright J.L."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Churg A."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Connett J.E."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Wise R.A."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Man S.F."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Sin D.D."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/author	"Tashkin D."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/date	"2013"xsd:gYear
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/name	"Am J Respir Crit Care Med"xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/pages	"1413-1419"xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/title	"Club cell protein 16 and disease progression in chronic obstructive pulmonary disease."xsd:string
http://purl.uniprot.org/citations/24245748	http://purl.uniprot.org/core/volume	"188"xsd:string
http://purl.uniprot.org/citations/24245748	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/24245748
http://purl.uniprot.org/citations/24245748	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/24245748
http://purl.uniprot.org/uniprot/#_A0A0S2Z4R6-mappedCitation-24245748	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24245748
http://purl.uniprot.org/uniprot/#_A0A0S2Z4L0-mappedCitation-24245748	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24245748
http://purl.uniprot.org/uniprot/#_Q06318-mappedCitation-24245748	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24245748
http://purl.uniprot.org/uniprot/#_Q3UKV9-mappedCitation-24245748	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24245748
http://purl.uniprot.org/uniprot/#_P11684-mappedCitation-24245748	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24245748