| http://purl.uniprot.org/citations/24248465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24248465 | http://www.w3.org/2000/01/rdf-schema#comment | "The perinatal period is critical for β-cell mass establishment, which is characterized by a transient burst in proliferation to increase β-cell mass in response to the need for glucose homeostasis throughout life. In adulthood, the ability of β-cells to grow, proliferate, and expand their mass is also characteristic of pathological states of insulin resistance. Translationally controlled tumor-associated protein (TCTP), an evolutionarily highly conserved protein that is implicated in cell growth and proliferation, has been identified as a novel glucose-regulated survival-supporting protein in pancreatic β-cells. In this study, the enhanced β-cell proliferation detected both during the perinatal developmental period and in insulin-resistant states in high-fat diet-fed mice was found to parallel the expression of TCTP in pancreatic β-cells. Specific knockout of TCTP in β-cells led to increased expression of total and nuclear Forkhead box protein O1 and tumor suppressor protein 53, and decreased expression of p70S6 kinase phosphorylation and cyclin D2 and cyclin-dependent kinase 2. This resulted in decreased β-cell proliferation and growth, reduced β-cell mass, and insulin secretion. Together, these effects led to hyperglycemia. These observations suggest that TCTP is essential for β-cell mass expansion during development and β-cell adaptation in response to insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2013-1663"xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/author | "Wu S.S."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/author | "Chen S.H."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/author | "Tsai M.J."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/author | "Yang-Yen H.F."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/author | "Wang M.J."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/author | "Chiang M.K."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/pages | "392-404"xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/title | "TCTP is essential for beta-cell proliferation and mass expansion during development and beta-cell adaptation in response to insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://purl.uniprot.org/core/volume | "155"xsd:string |
| http://purl.uniprot.org/citations/24248465 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24248465 |
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