| http://purl.uniprot.org/citations/24258346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24258346 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial-mesenchymal transition (EMT) has recently been recognized as a key element of cell invasion, migration, metastasis, and drug resistance in several types of cancer, including non-small cell lung cancer (NSCLC). Our aim was to clarify microRNA (miRNA)-related mechanisms underlying EMT followed by acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in NSCLC. miRNA expression profiles were examined before and after transforming growth factor β1 (TGF-β1) exposure in four human adenocarcinoma cell lines with or without EMT. Correlation between expressions of EMT-related miRNAs and resistance to EGFR-TKI gefitinib was evaluated. miRNA array and real-time quantitative reverse transcription PCR (qRT-PCR) revealed that TGF-β1 significantly induced overexpression of miR-134, miR-487b, and miR-655, which belong to the same cluster located on chromosome 14q32, in lung adenocarcinoma cells with EMT. MAGI2 (membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2), a predicted target of these miRNAs and a scaffold protein required for PTEN, was diminished in A549 cells with EMT after the TGF-β1 stimulation. Overexpression of miR-134 and miR-487b promoted the EMT phenomenon and affected the drug resistance to gefitinib, whereas knockdown of these miRNAs inhibited the EMT process and reversed TGF-β1-induced resistance to gefitinib. Our study demonstrated that the miR-134/487b/655 cluster contributed to the TGF-β1-induced EMT phenomenon and affected the resistance to gefitinib by directly targeting MAGI2, in which suppression subsequently caused loss of PTEN stability in lung cancer cells. The miR-134/miR-487b/miR-655 cluster may be a new therapeutic target in patients with advanced lung adenocarcinoma, depending on the EMT phenomenon."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.org/dc/terms/identifier | "doi:10.1158/1535-7163.mct-13-0448"xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Kubota K."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Matsuda K."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Kitamura K."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Mizutani H."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Miyanaga A."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Okano T."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Seike M."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Minegishi Y."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Gemma A."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/author | "Noro R."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/name | "Mol Cancer Ther"xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/pages | "444-453"xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/title | "MiR-134/487b/655 cluster regulates TGF-beta-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/24258346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24258346 |
| http://purl.uniprot.org/citations/24258346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24258346 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGF8-mappedCitation-24258346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24258346 |
| http://purl.uniprot.org/uniprot/#_B7Z4H4-mappedCitation-24258346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24258346 |
| http://purl.uniprot.org/uniprot/#_B7Z4N3-mappedCitation-24258346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24258346 |
| http://purl.uniprot.org/uniprot/#_B7Z5I0-mappedCitation-24258346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24258346 |
| http://purl.uniprot.org/uniprot/#_Q86UL8-mappedCitation-24258346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24258346 |