| http://purl.uniprot.org/citations/24260525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24260525 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitination and deubiquitination have emerged as critical regulatory processes in the virus-triggered type I interferon (IFN) induction pathway. In this study, we carried out a targeted siRNA screen of 54 ubiquitin-specific proteases (USPs) and identified USP25 as a negative regulator of the virus-triggered type I IFN signaling pathway. Overexpression of USP25 inhibited virus-induced activation of IFN-β, interferon regulation factor 3 (IRF3) and nuclear factor-kappa B (NF-κB), as well as the phosphorylation of IRF3 and NF-κB subunit p65. Furthermore, Knockdown of USP25 potentiated virus-induced induction of the IFN-β. In addition, detailed analysis demonstrated that USP25 cleaved lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo, and its deubiquitinating enzyme (DUB) activity, were dependent on a cysteine residue (Cys178) and a histidine residue (His607). USP25 mutants lacking DUB activity lost the ability to block virus-induced type I IFN to some degree. Mechanistically, USP25 deubiquitinated retinoic acid-inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling. Our findings suggest that USP25 is a novel DUB negatively regulating virus-induced type I IFN production."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0080976"xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Fang L."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Zhong H."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Luo R."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Ouyang C."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Shang M."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/author | "Ouyang H."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/pages | "e80976"xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/title | "Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling."xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24260525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24260525 |
| http://purl.uniprot.org/citations/24260525 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24260525 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV38-mappedCitation-24260525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24260525 |
| http://purl.uniprot.org/uniprot/#_B5BUQ5-mappedCitation-24260525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24260525 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-24260525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24260525 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-24260525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24260525 |
| http://purl.uniprot.org/uniprot/#_P01574-mappedCitation-24260525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24260525 |