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http://purl.uniprot.org/citations/24261225http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24261225http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To define a role of connexin37 (Cx37) C1019T and endothelial nitric oxide synthase (eNOS) G894T polymorphisms in the development of myocardial infarction (MI) in subjects without a history of coronary artery disease.

Subjects and results

The investigation enrolled 183 male patients, of whom 56 (18.1%) developed MI in the presence of clinically and instrumentally verified coronary heart disease (CHD) (except MI) and 127 (81.9%) patients did without any previous clinical signs of CHD. The gene polymorphisms were identified using polymerase chain reaction and restriction fragment length polymorphism analysis.

Results

The spread of the G allele in the eNOS gene was 59.8% in the patients with MI in the presence of CHD and 75.6% in those with MI without a history of coronary artery disease (p<0.01). The GG genotype was found in 32.1 and 54.3%, respectively (p=0.01; the odds ratio (OR) was 2.5 with 95% confidence interval (CI) 1.3 to 4.9). The spread of the mutant T allele in the Cx37 gene was 29.5% in the patients with MI in the presence of CHD and 59.8% in those with MI without a history of coronary artery disease (p<0.01). The TT genotype was encountered in 7.1 and 42.5% of cases, respectively (p=0.01; OR 9.6 with 95% CI 3.3 to 28.4). There was no case of a combination of GG and TT genotypes among the patients with MI in the presence of CHD whereas this was found in 23.6% of the MI cases without a history of coronary artery disease (p<0.01).

Conclusion

Determination of Cx37 C1019T and eNOS G894T polymorphisms may be used to detect a genetic predisposition to the development of MI in patients with hemodynamically insignificant atherosclerosis and in apparently healthy individuals."xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/author"Tkachuk V.A."xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/author"Boitsov S.A."xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/author"Samokhodskaya L.M."xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/author"Balatskii A.V."xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/author"Andreenko E.Y."xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/name"Ter Arkh"xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/pages"18-22"xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/title"[Endothelial NO synthase and connexin 37 gene polymorphisms as a risk factor for myocardial infarction in subjects without a history of coronary artery disease]."xsd:string
http://purl.uniprot.org/citations/24261225http://purl.uniprot.org/core/volume"85"xsd:string
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