| http://purl.uniprot.org/citations/24262987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24262987 | http://www.w3.org/2000/01/rdf-schema#comment | "The thyroid hormone, T 3, regulates cell growth, differentiation and development through binding to the nuclear thyroid hormone receptor (THR), a member of the steroid/TR superfamily of ligand-dependent transcriptional factors. T 3 modulates lipid metabolism in liver, although the detailed molecular mechanisms are unclear at present. Here, by a microarray analysis, we identified a novel chromosome 19 open reading frame 80 (C19orf80) which was activated by T 3. T 3 stimulation led to upregulation of both mRNA and protein levels of C19orf80. Immunofluorescence analysis revealed a vesicle-like pattern of C19orf80 around lipid droplets or within the lysosome-associated compartment in cells. Furthermore, T 3 treatment as well as C19orf80 overexpression specifically activated the autophagic response and lipid metabolism, as observed from lipidated LC3 (LC3-II) and levels of oxygen consumption rate, respectively. Reciprocally, knockdown of C19orf80 obstructed T 3-activated autophagy and lipolysis. Moreover, treatment with autolysosome maturation inhibitors, ammonium chloride and chloroquine, not only suppressed the T 3-activated autophagic process but also lipid metabolism. Our results collectively suggested that T 3 regulates lipid metabolism through a C19orf80-activated autophagic process."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.org/dc/terms/identifier | "doi:10.4161/auto.26126"xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Chen C.Y."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Chi H.C."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Lin Y.H."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Tseng Y.H."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Liao C.J."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Wu S.M."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Lin K.H."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Tsai C.Y."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/author | "Ke P.Y."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/name | "Autophagy"xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/pages | "20-31"xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/title | "Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism."xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/24262987 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24262987 |
| http://purl.uniprot.org/citations/24262987 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24262987 |
| http://purl.uniprot.org/uniprot/#_K7EIY2-mappedCitation-24262987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24262987 |
| http://purl.uniprot.org/uniprot/#_Q29RX7-mappedCitation-24262987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24262987 |
| http://purl.uniprot.org/uniprot/#_Q6UXH0-mappedCitation-24262987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24262987 |
| http://purl.uniprot.org/uniprot/#_W5VK78-mappedCitation-24262987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24262987 |
| http://purl.uniprot.org/uniprot/#_W5VKF7-mappedCitation-24262987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24262987 |
| http://purl.uniprot.org/uniprot/#_W5VKV0-mappedCitation-24262987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24262987 |