| http://purl.uniprot.org/citations/24263861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24263861 | http://www.w3.org/2000/01/rdf-schema#comment | "Viruses sometimes mimic host proteins and hijack the host cell machinery. Hepatitis C virus (HCV) causes liver fibrosis, a process largely mediated by the overexpression of transforming growth factor (TGF)-β and collagen, although the precise underlying mechanism is unknown. Here, we report that HCV non-structural protein 3 (NS3) protease affects the antigenicity and bioactivity of TGF-β2 in (CAGA)9-Luc CCL64 cells and in human hepatic cell lines via binding to TGF-β type I receptor (TβRI). Tumor necrosis factor (TNF)-α facilitates this mechanism by increasing the colocalization of TβRI with NS3 protease on the surface of HCV-infected cells. An anti-NS3 antibody against computationally predicted binding sites for TβRI blocked the TGF-β mimetic activities of NS3 in vitro and attenuated liver fibrosis in HCV-infected chimeric mice. These data suggest that HCV NS3 protease mimics TGF-β2 and functions, at least in part, via directly binding to and activating TβRI, thereby enhancing liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep03243"xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Kojima S."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Shirouzu M."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Sakata K."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Terada T."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Takaya D."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Imoto M."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Matsuura T."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Hara M."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Miyazawa K."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Wakita T."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Aizaki H."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/author | "Yaguchi S."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/pages | "3243"xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/title | "HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor."xsd:string |
| http://purl.uniprot.org/citations/24263861 | http://purl.uniprot.org/core/volume | "3"xsd:string |