| http://purl.uniprot.org/citations/24269820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24269820 | http://www.w3.org/2000/01/rdf-schema#comment | "Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3(-/-) mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3(-/-) mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3(-/-) mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3(-/-) mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2013.11.040"xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Kubo S."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Shimizu K."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Saijo S."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Kakuta S."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Maruhashi T."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Seno A."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/author | "Murayama M.A."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/pages | "42-48"xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/title | "CTRP3 plays an important role in the development of collagen-induced arthritis in mice."xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://purl.uniprot.org/core/volume | "443"xsd:string |
| http://purl.uniprot.org/citations/24269820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24269820 |
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| http://purl.uniprot.org/uniprot/Q4ZJN6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24269820 |
| http://purl.uniprot.org/uniprot/Q9ES30 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24269820 |