| http://purl.uniprot.org/citations/24269955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24269955 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor-D (VEGFD) is a potent pro-lymphangiogenic molecule during tumor growth and is considered a key therapeutic target to modulate metastasis. Despite roles in pathological neo-lymphangiogenesis, the characterization of an endogenous role for VEGFD in vascular development has remained elusive. Here, we used zebrafish to assay for genetic interactions between the Vegf/Vegf-receptor pathway and SoxF transcription factors and identified a specific interaction between Vegfd and Sox18. Double knockdown zebrafish embryos for Sox18/Vegfd and Sox7/Vegfd exhibit defects in arteriovenous differentiation. Supporting this observation, we found that Sox18/Vegfd double but not single knockout mice displayed dramatic vascular development defects. We find that VEGFD-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling modulates SOX18-mediated transcription, functioning at least in part by enhancing nuclear concentration and transcriptional activity in vascular endothelial cells. This work suggests that VEGFD-mediated pathologies include or involve an underlying dysregulation of SOXF-mediated transcriptional networks."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-04-495432"xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Smith K.A."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Duong T."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Achen M.G."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Fontaine F."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Koopman P."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Truong V."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Hogan B.M."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Francois M."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Stacker S.A."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Pichol-Thievend C."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Le Guen L."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Koltowska K."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/author | "Skoczylas R."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/pages | "1102-1112"xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/title | "VEGFD regulates blood vascular development by modulating SOX18 activity."xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/24269955 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24269955 |
| http://purl.uniprot.org/citations/24269955 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24269955 |
| http://purl.uniprot.org/uniprot/A0A8M3AXQ4#attribution-7F13C6783A67835058F701EE6F79B796 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24269955 |
| http://purl.uniprot.org/uniprot/Q208T6#attribution-7F13C6783A67835058F701EE6F79B796 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24269955 |