| http://purl.uniprot.org/citations/24270572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24270572 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA damage-induced activation of the transcription factor NF-κB plays an important role in the cellular response to genotoxic stress. However, uncontrolled NF-κB activation upon DNA damage may lead to deleterious consequences. Although the mechanisms mediating genotoxic NF-κB activation have been elucidated, how this signalling is terminated remains poorly understood. Here, we show that the CCCH-type zinc finger-containing protein MCPIP1 (monocyte chemotactic protein-1-induced protein-1; also known as ZC3H12A) is induced upon genotoxic treatment in an NF-κB-dependent manner. MCPIP1 upregulation reduces NEMO linear ubiquitylation, resulting in decreased activation of IKK and NF-κB. NEMO ubiquitylation is decreased through the deubiquitinase USP10, which interacts with NEMO via MCPIP1 upon genotoxic stress. USP10 association with NEMO leads to removal of NEMO-attached linear polyubiquitin chains and subsequent inhibition of the genotoxic NF-κB signalling cascade. Consistently, USP10 is required for MCPIP1-mediated inhibition of genotoxic NF-κB activation and promotion of apoptosis. Thus, by mediating USP10-dependent deubiquitination of NEMO, MCPIP1 induction serves as a negative feedback mechanism for attenuating genotoxic NF-κB activation."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.247"xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Fu M."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Niu J."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Wu Z.H."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Xue J."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/author | "Miao R."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/pages | "3206-3219"xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/title | "USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitated deubiquitination of NEMO."xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/24270572 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24270572 |
| http://purl.uniprot.org/citations/24270572 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24270572 |
| http://purl.uniprot.org/uniprot/#_A0A087X1B1-mappedCitation-24270572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24270572 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0T4-mappedCitation-24270572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24270572 |
| http://purl.uniprot.org/uniprot/#_D3YYY3-mappedCitation-24270572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24270572 |
| http://purl.uniprot.org/uniprot/#_D3Z216-mappedCitation-24270572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24270572 |
| http://purl.uniprot.org/uniprot/#_D3Z564-mappedCitation-24270572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24270572 |
| http://purl.uniprot.org/uniprot/#_B3KSD3-mappedCitation-24270572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24270572 |