| http://purl.uniprot.org/citations/24275181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24275181 | http://www.w3.org/2000/01/rdf-schema#comment | "The glucagon-like peptide-1 incretin receptor (GLP-1R) of family B G protein-coupled receptors (GPCRs) is a major drug target in type-2-diabetes due to its regulatory effect on post-prandial blood-glucose levels. The mechanism(s) controlling GLP-1R mediated signaling are far from fully understood. A fundamental mechanism controlling the signaling capacity of GPCRs is the post-endocytic trafficking of receptors between recycling and degradative fates. Here, we combined microscopy with novel real-time assays to monitor both receptor trafficking and signaling in living cells. We find that the human GLP-1R internalizes rapidly and with similar kinetics in response to equipotent concentrations of GLP-1 and the stable GLP-1 analogues exendin-4 and liraglutide. Receptor internalization was confirmed in mouse pancreatic islets. GLP-1R is shown to be a recycling receptor with faster recycling rates mediated by GLP-1 as compared to exendin-4 and liraglutide. Furthermore, a prolonged cycling of ligand-activated GLP-1Rs was observed and is suggested to be correlated with a prolonged cAMP signal."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2013.11.010"xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Secher A."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Whistler J.L."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Waldhoer M."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Lehtonen J."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Knudsen S.M."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Kulahin N."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Schaffer L."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Underwood C.R."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Brauner-Osborne H."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Mathiesen J.M."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Cappelen K.A."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Hecksher-Soerensen J."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Iversen H."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Roed S.N."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/author | "Wismann P."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/pages | "938-949"xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/title | "Real-time trafficking and signaling of the glucagon-like peptide-1 receptor."xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://purl.uniprot.org/core/volume | "382"xsd:string |
| http://purl.uniprot.org/citations/24275181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24275181 |
| http://purl.uniprot.org/citations/24275181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24275181 |