| http://purl.uniprot.org/citations/24276238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24276238 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung cancer is the leading cause of cancer deaths worldwide with non small-cell lung cancer (NSCLC) accounting for 80% of all lung cancers. Although activating mutations in genes of the RAS-MAPK pathway occur in up to 30% of all NSCLC, the cooperating genetic lesions that are required for lung cancer initiation and progression remain poorly understood. Here we identify a role for the cell polarity regulator Scribble (Scrib) in NSCLC. A survey of genomic databases reveals deregulation of SCRIB in human lung cancer and we show that Scrib(+/-) mutant mice develop lung cancer by 540 days with a penetrance of 43%. To model NSCLC development in vivo, we used the extensively characterized LSL-KRas(G12D) murine model of NSCLC. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors, likely due to a synergistic elevation in RAS-MAPK signaling. Finally, we provide data consistent with immune infiltration having an important role in the acceleration of tumorigenesis in KRas(G12D) lung tumors following Scrib loss."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2013.498"xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Long F."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Ernst M."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Phesse T.J."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Humbert P.O."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Elsum I.A."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Cullinane C."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Pearson H.B."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "Yates L.L."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/author | "O'Donoghue R."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/pages | "5523-5533"xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/title | "Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo."xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/24276238 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24276238 |
| http://purl.uniprot.org/citations/24276238 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24276238 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JNZ2-mappedCitation-24276238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24276238 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JPP5-mappedCitation-24276238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24276238 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ1-mappedCitation-24276238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24276238 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY1-mappedCitation-24276238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24276238 |
| http://purl.uniprot.org/uniprot/#_D3YVA3-mappedCitation-24276238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24276238 |
| http://purl.uniprot.org/uniprot/#_Q0VDV7-mappedCitation-24276238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24276238 |