| http://purl.uniprot.org/citations/24278461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24278461 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0081833"xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Peschel C."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Gross O."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Ruland J."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Dyer M.J."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Forster I."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Gewies A."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Schroeder T."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Hrabe de Angelis M."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Beckers J."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Horsch M."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Przemeck G.K."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Karran E.L."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Majid A."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Heinrich K."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Ferch U."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Dodt H.U."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Munding M."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Jahrling N."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Antonowicz S."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Castineiras-Vilarino M."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/author | "Hoeckendorf U."xsd:string |
| http://purl.uniprot.org/citations/24278461 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |