| http://purl.uniprot.org/citations/24284797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24284797 | http://www.w3.org/2000/01/rdf-schema#comment | "Serine/arginine-rich splicing factor 3 (SRSF3) is a member of the SR protein family and plays wide-ranging roles in gene expression. The human SRSF3 gene generates two alternative splice transcripts, a major mRNA isoform (SRSF3-FL) encoding functional full-length protein and a premature termination codon (PTC)-containing isoform (SRSF3-PTC). The latter is degraded through nonsense-mediated mRNA decay (NMD). Treatment of a human colon cancer cell line (HCT116) with 100 μM sodium arsenite increased SRSF3-PTC mRNA levels without changing SRSF3-FL mRNA levels. A chemiluminescence-based NMD reporter assay system demonstrated that arsenite treatment inhibited NMD activity and increased SRSF3-PTC mRNA levels in the cytoplasm, facilitating translation of a truncated SRSF3 protein (SRSF3-TR) from SRSF3-PTC mRNA. SRSF3-TR lacked two-thirds of the Arg/Ser-rich (RS) domain whose phosphorylation state is known to be crucial for subcellular distribution. SRSF3-FL was localized in the nucleus, while overexpressed SRSF3-TR was diffusely distributed in the cytoplasm and the nucleus. A part of SRSF3-TR was also associated with stress granules in the cytoplasm. Interestingly, treatment of HCT116 cells with a small interference RNA specifically targeting SRSF3-PTC mRNA significantly attenuated arsenite-stimulated induction of c-JUN protein, its binding activity to the AP-1 binding site (-126 to 120 bp) in the interleukin (IL)-8 gene promoter, and AP-1 promoter activity, resulting in significant reduction of arsenite-stimulated IL-8 production. Our results suggest that SRSF3-TR may function as a positive regulator of oxidative stress-initiated inflammatory responses in colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00091.2013"xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Kurokawa K."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Nishida K."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Nishiyama C."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Masuda K."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Kita K."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Kano S."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Tanahashi T."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Kuwano Y."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Rokutan K."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Kajita K."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Akaike Y."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/author | "Kurebe H."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/pages | "C250-62"xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/title | "Oxidative stress-inducible truncated serine/arginine-rich splicing factor 3 regulates interleukin-8 production in human colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://purl.uniprot.org/core/volume | "306"xsd:string |
| http://purl.uniprot.org/citations/24284797 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24284797 |
| http://purl.uniprot.org/citations/24284797 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24284797 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-24284797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24284797 |
| http://purl.uniprot.org/uniprot/#_B2R6F3-mappedCitation-24284797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24284797 |
| http://purl.uniprot.org/uniprot/#_P10145-mappedCitation-24284797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24284797 |