| http://purl.uniprot.org/citations/24286455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24286455 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionHLA-B27 genotyping is commonly used to support a diagnosis of ankylosing spondylitis (AS). A recent study has suggested that HLA-B27 may adversely affect longevity. The objectives of this study were to determine, for the first time, the prevalence of HLA-B27 in the New Zealand population, and to test whether HLA-B27 prevalence declines with age.Methods117 Caucasian controls, 111 New Zealand Māori controls, and 176 AS patients were directly genotyped for HLA-B27 using PCR-SSP. These participants and a further 1103 Caucasian controls were genotyped for the HLA-B27 tagging single nucleotide polymorphisms (SNPs) rs4349859 and rs116488202. All AS patients testing positive for HLA-B27 of New Zealand Māori ancestry underwent high resolution typing to determine sub-allele status.ResultsHLA-B27 prevalence was 9.2% in New Zealand Caucasian controls and 6.5% in Māori controls. No decline in HLA-B27 prevalence with age was detected in Caucasian controls (p = 0.92). Concordance between HLA-B27 and SNP genotypes was 98.7-99.3% in Caucasians and 76.9-86% in Māori. Of the 14 AS patients of Māori ancestry, 1 was negative for HLA-B27, 10 were positive for HLAB*2705, and 3 positive for HLAB*2704. All cases of genotype discordance were explained by the presence of HLAB*2704.ConclusionsHLA-B27 prevalence in New Zealand Caucasians is consistent with that of Northern European populations and did not decline with increasing age. In Māori with AS who were HLA-B27 positive, 76.9% were positive for HLA-B*2705, suggesting that genetic susceptibility to AS in Māori is primarily due to admixture with Caucasians."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.org/dc/terms/identifier | "doi:10.1186/ar4341"xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Harrison A."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "White D."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Jones G.T."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "van Rij A.M."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Roberts R.L."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Wallace M.C."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Merriman T.R."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Highton J."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Stamp L.K."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Stebbings S.M."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/author | "Ching D."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/name | "Arthritis Res Ther"xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/pages | "R158"xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/title | "Prevalence of HLA-B27 in the New Zealand population: effect of age and ethnicity."xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/24286455 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24286455 |
| http://purl.uniprot.org/citations/24286455 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24286455 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-24286455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24286455 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-24286455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24286455 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-24286455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24286455 |