| http://purl.uniprot.org/citations/24287892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24287892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24287892 | http://www.w3.org/2000/01/rdf-schema#comment | "Zebrafish (Danio rerio) are a valuable model for studying immunity, infection, and hematopoietic disease and have recently been employed for transplantation assays. However, the lack of syngeneic zebrafish creates challenges with identifying immune-matched individuals. The MHC class I genes, which mediate allogeneic recognition in mammals, have been grouped into three broad lineages in zebrafish: the classical U genes on chromosome 19, the Z genes which have been reported to map to chromosome 1, and the L genes that map to multiple loci. Transplantations between individual zebrafish that are matched at the U locus fail to consistently engraft suggesting that additional loci contribute to allogeneic recognition. Although two full-length zebrafish Z transcripts have been described, the genomic organization and diversity of these genes have not been reported. Herein we define ten Z genes on chromosomes 1 and 3 and on an unplaced genomic scaffold. We report that neither of the Z transcripts previously described match the current genome assembly and classify these transcripts as additional gene loci. We characterize full-length transcripts for 9 of these 12 genes. We demonstrate a high level of expression variation of the Z genes between individual zebrafish suggestive of haplotypic variation. We report low level sequence variation for individual Z genes between individual zebrafish reflecting a possible nonclassical function, although these molecules may still contribute to allogeneic recognition. Finally, we present a gene nomenclature system for the Z genes consistent with MHC nomenclature in other species and with the zebrafish gene nomenclature guidelines."xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-013-0748-z"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-013-0748-z"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/author | "Yoder J.A."xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/author | "Yoder J.A."xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/author | "Dirscherl H."xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/author | "Dirscherl H."xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/pages | "185-198"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/pages | "185-198"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/title | "Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish."xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/title | "Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish."xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/24287892 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24287892 |
| http://purl.uniprot.org/citations/24287892 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24287892 |
| http://purl.uniprot.org/citations/24287892 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24287892 |
| http://purl.uniprot.org/citations/24287892 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24287892 |
| http://purl.uniprot.org/uniprot/Q566P2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/24287892 |
| http://purl.uniprot.org/uniprot/A8E7F2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/24287892 |