| http://purl.uniprot.org/citations/24289923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24289923 | http://www.w3.org/2000/01/rdf-schema#comment | "The breast and ovarian cancer-specific tumor suppressor BRCA1, along with its heterodimer partner BRCA1-associated RING domain protein (BARD1), plays important roles in DNA repair, centrosome regulation, and transcription. To explore further functions of BRCA1/BARD1, we performed mass spectrometry analysis and identified Obg-like ATPase 1 (OLA1) as a protein that interacts with the carboxy-terminal region of BARD1. OLA1 directly bound to the amino-terminal region of BRCA1 and γ-tubulin. OLA1 localized to centrosomes in interphase and to the spindle pole in mitotic phase, and its knockdown resulted in centrosome amplification and the activation of microtubule aster formation. OLA1 with a mutation observed in breast cancer cell line, E168Q, failed to bind BRCA1 and rescue the OLA1 knockdown-induced centrosome amplification. BRCA1 variant I42V also abrogated the binding of BRCA1 to OLA1. These findings suggest that OLA1 plays an important role in centrosome regulation together with BRCA1."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.10.028"xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Kato K."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Shibata S."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Wei L."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Furukawa Y."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Chiba N."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Yasui A."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Kanno S."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Shimaoka T."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Ishioka C."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/author | "Mochiduki H."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/pages | "101-114"xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/title | "The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation."xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/24289923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24289923 |
| http://purl.uniprot.org/citations/24289923 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24289923 |
| http://purl.uniprot.org/uniprot/#_B4DK14-mappedCitation-24289923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24289923 |
| http://purl.uniprot.org/uniprot/#_Q53SQ6-mappedCitation-24289923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24289923 |
| http://purl.uniprot.org/uniprot/#_Q53SW9-mappedCitation-24289923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24289923 |