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| http://purl.uniprot.org/citations/24293364 | http://www.w3.org/2000/01/rdf-schema#comment | "Tropoelastin protein monomers assemble to form elastin. Cellular integrin αVβ3 binds RKRK at the C-terminal tail of tropoelastin. We probed cell interactions with tropoelastin by deleting the RKRK sequence to identify other cell-binding interactions within tropoelastin. We found a novel human dermal fibroblast attachment and spreading site on tropoelastin that is located centrally in the molecule. Inhibition studies demonstrated that this cell adhesion was not mediated by either elastin-binding protein or glycosaminoglycans. Cell interactions were divalent cation-dependent, indicating integrin dependence. Function-blocking monoclonal antibodies revealed that αV integrin(s) and integrin αVβ5 specifically were critical for cell adhesion to this part of tropoelastin. These data reveal a common αV integrin-binding theme for tropoelastin: αVβ3 at the C terminus and αVβ5 at the central region of tropoelastin. Each αV region contributes to fibroblast attachment and spreading, but they differ in their effects on cytoskeletal assembly."xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.518381"xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/author | "Lee P."xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/author | "Weiss A.S."xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/author | "Bax D.V."xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/author | "Bilek M.M."xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/pages | "1467-1477"xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/title | "A novel cell adhesion region in tropoelastin mediates attachment to integrin alphaVbeta5."xsd:string |
| http://purl.uniprot.org/citations/24293364 | http://purl.uniprot.org/core/volume | "289"xsd:string |
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