| http://purl.uniprot.org/citations/24294380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24294380 | http://www.w3.org/2000/01/rdf-schema#comment | "Diagnosing arrhythmogenic right ventricular cardiomyopathy (ARVC) is often challenging because no single diagnostic tool is available to detect the disease. We evaluated whether analysis of plakoglobin, N-cadherin, and connexin-43 immunoreactivity can be used as a significant test in diagnosis of ARVC. We selected subjects with suspicion of ARVC (n=22) in patients who underwent endomyocardial biopsy (EMB) in Kyungpook National University Hospital (n=1326). The patients (n=22) were classified into definite ARVC patients (n=17) and borderline ARVC (n=5). We selected control subjects (n=20) who were autopsied and died of non-cardiac disease. Hematoxylin-eosin, Masson's trichrome, and immunohistochemical stains for plakoglobin, N-cadherin, and connexin-43 were used for all specimens. Reduced immunoreactivity of plakoglobin was observed in 13 (76%) of the 17 patients with a definite ARVC and in 4 (80%) of the 5 patients with a borderline ARVC. All subjects displayed no significant reduction of the immunoreactivity for connexin-43 as well as for N-cadherin. Our investigation revealed that the immunohistochemical analysis for plakoglobin had an accuracy of 81%, 76% sensitivity, and 84% specificity in diagnosis of ARVC. Results of our study showed that the immunohistochemical analysis of plakoglobin had a relatively high sensitivity and specificity in ARVC, but immunohistochemistry for plakoglobin alone could not be relied upon as a diagnostic test for ARVC. We confirmed that N-cadherin and connexin-43 had no diagnostic value in ARVC."xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/author | "Cho Y."xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/author | "Kwon Y.S."xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/author | "Park T.I."xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/author | "Bae M.H."xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/name | "Int J Clin Exp Pathol"xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/pages | "2928-2935"xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/title | "Clinical usefulness of immunohistochemistry for plakoglobin, N-cadherin, and connexin-43 in the diagnosis of arrhythmogenic right ventricular cardiomyopathy."xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/24294380 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24294380 |
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