| http://purl.uniprot.org/citations/24296759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24296759 | http://www.w3.org/2000/01/rdf-schema#comment | "UnlabelledWe report that HMGN1, a nucleosome-binding protein that affects chromatin structure and function, affects the growth of N-nitrosodiethylamine (DEN)-induced liver tumors. Following a single DEN injection at 2 weeks of age, Hmgn1(tm1/tm1) mice, lacking the nucleosome-binding domain of HMGN1, had earlier signs of liver tumorigenesis than their Hmgn1(+/+) littermates. Detailed gene expression profiling revealed significant differences between DEN-injected and control saline-injected mice, but only minor differences between the injected Hmgn1(tm1/tm1) mice and their Hmgn1(+/+) littermates. Pathway analysis revealed that the most significant process affected by loss of HMGN1 involves the lipid/sterol metabolic pathway. Our study indicates that in mice, loss of HMGN1 leads to transcription changes that accelerate the progression of DEN-induced hepatocarcinogenesis, without affecting the type of tumors or the final total tumor burden of these mice.ImplicationsLoss of HMGN1 leads to accelerated progression of DEN-induced hepatocarcinogenesis in mice."xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-13-0392"xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/author | "Furusawa T."xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/author | "Haines D.C."xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/author | "Factor V.M."xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/author | "Bustin M."xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/author | "Postnikov Y.V."xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/name | "Mol Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/pages | "82-90"xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/title | "Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice."xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/24296759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24296759 |
| http://purl.uniprot.org/citations/24296759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24296759 |
| http://purl.uniprot.org/uniprot/#_A0A3B2W3M7-mappedCitation-24296759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24296759 |
| http://purl.uniprot.org/uniprot/#_P18608-mappedCitation-24296759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24296759 |
| http://purl.uniprot.org/uniprot/#_Q8CEW1-mappedCitation-24296759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24296759 |
| http://purl.uniprot.org/uniprot/P18608 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24296759 |
| http://purl.uniprot.org/uniprot/A0A3B2W3M7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24296759 |
| http://purl.uniprot.org/uniprot/Q8CEW1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24296759 |