| http://purl.uniprot.org/citations/24299318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24299318 | http://www.w3.org/2000/01/rdf-schema#comment | "This article aimed to investigate the value of α-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC) and to evaluate the relationship between AFP and various clinical variables of HCC comprehensively. A retrospective study of postoperative patients diagnosed with liver neoplasm from two Chinese centers was enrolled in our study.A total of 3050 patients were included. The best cut-off point of AFP for the diagnosis of HCC was 20ng/ml with ideal sensitivity (69.74%), specificity (91.18%), LR (4.12) and YI (0.61). Non-HBV infection patients showed the highest specificity (94.44%) but lowest sensitivity (60.13%). In HBV infection. Patients, HBsAg, HBeAb, and HBcAb positive patients had the highest sensitivity (79.55%) and specificity (58.49%). AFP levels increased significantly in symptomatic patients (p=0.011). Those patients with tumor sizes ≥10cm had much higher serum AFP level compared with smaller tumors ones (p=0.014). AFP levels increased remarkably in patients with vascular invasion (p=0.015). Stepwise logistic regression showed tumor size (≥10cm) was an independent predictor of elevated AFP (OR=2.743, 95%CI: 1.167-6.447, P=0.021). The best discriminating AFP value for the diagnosis of HCC is 20ng/ml; HBsAg, HBeAb and HBcAb positive patients have the optimal sensitivity and specificity; tumor size ≥ 10cm is an independent predictor of elevated AFP."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.org/dc/terms/identifier | "doi:10.4149/neo_2014_028"xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/author | "Xu G."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/author | "Zhang J.H."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/author | "Qin L.X."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/author | "Chen G.F."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/author | "Xu J.B."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/author | "Qi F.Z."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/name | "Neoplasma"xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/pages | "218-224"xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/title | "Value of alpha-fetoprotein and clinical characteristics in patients with liver neoplasm."xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/24299318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24299318 |
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