| http://purl.uniprot.org/citations/24310611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24310611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24310611 | http://www.w3.org/2000/01/rdf-schema#comment | "In budding yeast, one-ended DNA double-strand breaks (DSBs) and damaged replication forks are repaired by break-induced replication (BIR), a homologous recombination pathway that requires the Pol32 subunit of DNA polymerase delta. DNA replication stress is prevalent in cancer, but BIR has not been characterized in mammals. In a cyclin E overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis. Segmental genomic duplications induced by cyclin E overexpression were also dependent on POLD3, as were BIR-mediated recombination events captured with a specialized DSB repair assay. We propose that BIR repairs damaged replication forks in mammals, accounting for the high frequency of genomic duplications in human cancers."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1243211"xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1243211"xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Helleday T."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Helleday T."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Haber J.E."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Haber J.E."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Halazonetis T.D."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Halazonetis T.D."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Kallioniemi O.P."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Kallioniemi O.P."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Costantino L."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Costantino L."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Iliakis G."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Iliakis G."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Magin S."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Magin S."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Mladenov E."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Mladenov E."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Rantala J.K."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Rantala J.K."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Sotiriou S.K."xsd:string |
| http://purl.uniprot.org/citations/24310611 | http://purl.uniprot.org/core/author | "Sotiriou S.K."xsd:string |