| http://purl.uniprot.org/citations/24311690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24311690 | http://www.w3.org/2000/01/rdf-schema#comment | "Host cell factor-1 (HCF-1), a transcriptional co-regulator of human cell-cycle progression, undergoes proteolytic maturation in which any of six repeated sequences is cleaved by the nutrient-responsive glycosyltransferase, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT). We report that the tetratricopeptide-repeat domain of O-GlcNAc transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase active site above uridine diphosphate-GlcNAc. The conformation is similar to that of a glycosylation-competent peptide substrate. Cleavage occurs between cysteine and glutamate residues and results in a pyroglutamate product. Conversion of the cleavage site glutamate into serine converts an HCF-1 proteolytic repeat into a glycosylation substrate. Thus, protein glycosylation and HCF-1 cleavage occur in the same active site."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1243990"xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Walker S."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Herr W."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Vocadlo D.J."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Lazarus M.B."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Zandberg W.F."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Bhuiyan T."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Kapuria V."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/author | "Janetzko J."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/pages | "1235-1239"xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/title | "HCF-1 is cleaved in the active site of O-GlcNAc transferase."xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://purl.uniprot.org/core/volume | "342"xsd:string |
| http://purl.uniprot.org/citations/24311690 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24311690 |
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| http://purl.uniprot.org/uniprot/A0A223PQH6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24311690 |
| http://purl.uniprot.org/uniprot/P51610 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24311690 |