| http://purl.uniprot.org/citations/24316072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24316072 | http://www.w3.org/2000/01/rdf-schema#comment | "The transition from transcription initiation into elongation is controlled by transcription factors, which recruit positive transcription elongation factor b (P-TEFb) to promoters to phosphorylate RNA polymerase II. A fraction of P-TEFb is recruited as part of the inhibitory 7SK small nuclear ribonucleoprotein particle (snRNP), which inactivates the kinase and prevents elongation. However, it is unclear how P-TEFb is captured from the promoter-bound 7SK snRNP to activate elongation. Here, we describe a mechanism by which transcription factors mediate the enzymatic release of P-TEFb from the 7SK snRNP at promoters to trigger activation in a gene-specific manner. We demonstrate that Tat recruits PPM1G/PP2Cγ to locally disassemble P-TEFb from the 7SK snRNP at the HIV promoter via dephosphorylation of the kinase T loop. Similar to Tat, nuclear factor (NF)-κB recruits PPM1G in a stimulus-dependent manner to activate elongation at inflammatory-responsive genes. Recruitment of PPM1G to promoter-assembled 7SK snRNP provides a paradigm for rapid gene activation through transcriptional pause release."xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2013.11.003"xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/author | "Gudipaty S.A."xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/author | "McCann J.L."xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/author | "D'Orso I."xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/author | "McNamara R.P."xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/pages | "1256-1268"xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/title | "Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation."xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24316072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24316072 |
| http://purl.uniprot.org/citations/24316072 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24316072 |
| http://purl.uniprot.org/uniprot/#_B4DDC8-mappedCitation-24316072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24316072 |
| http://purl.uniprot.org/uniprot/#_B3KXL8-mappedCitation-24316072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24316072 |
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| http://purl.uniprot.org/uniprot/#_O15355-mappedCitation-24316072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24316072 |
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| http://purl.uniprot.org/uniprot/#_Q59GB2-mappedCitation-24316072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24316072 |
| http://purl.uniprot.org/uniprot/#_Q6PJK3-mappedCitation-24316072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24316072 |
| http://purl.uniprot.org/uniprot/#_Q6IAU5-mappedCitation-24316072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24316072 |
| http://purl.uniprot.org/uniprot/Q96IN7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24316072 |
| http://purl.uniprot.org/uniprot/Q59GB2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24316072 |
| http://purl.uniprot.org/uniprot/B2R665 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24316072 |