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http://purl.uniprot.org/citations/24316228http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24316228http://www.w3.org/2000/01/rdf-schema#comment"The N-terminal 1-83 residues of apolipoprotein A-I (apoA-I) have a strong propensity to form amyloid fibrils, in which the 46-59 segment was reported to aggregate to form amyloid-like fibrils. In this study, we demonstrated that a fragment peptide comprising the extreme N-terminal 1-43 residues strongly forms amyloid fibrils with a transition to β-sheet-rich structure, and that the G26R point mutation enhances the fibril formation of this segment. Our results suggest that in addition to the 46-59 segment, the extreme N-terminal region plays a crucial role in the development of amyloid fibrils by the N-terminal fragment of amyloidogenic apoA-I variants."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2013.11.031"xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Kosaka A."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Tsuji K."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Saito H."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Nagao K."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Kawashima H."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Akaji K."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Shigenaga A."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Adachi E."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Otaka A."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/author"Mizuguchi C."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/pages"389-394"xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/title"The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils."xsd:string
http://purl.uniprot.org/citations/24316228http://purl.uniprot.org/core/volume"588"xsd:string
http://purl.uniprot.org/citations/24316228http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24316228
http://purl.uniprot.org/citations/24316228http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24316228
http://purl.uniprot.org/uniprot/P02647#attribution-DC121F0B698D6A5749D883A92F7BC795http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/24316228
http://purl.uniprot.org/uniprot/#_P02647-mappedCitation-24316228http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24316228
http://purl.uniprot.org/uniprot/P02647http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24316228