| http://purl.uniprot.org/citations/24319288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24319288 | http://www.w3.org/2000/01/rdf-schema#comment | "Endocannabinoids are lipid-signaling molecules found in the nervous system; however, their precise role in the periphery is unclear. In the current study, we observed that a single i.p. administration of AEA caused rapid induction of MDSCs. The MDSCs contained a mixture of granulocytic and monocytic subtypes and expressed Arg-1 and iNOS. The MDSCs suppressed T cell proliferation in vitro and used iNOS to mediate their effect. Moreover, adoptive transfer of MDSCs led to suppression of mBSA-induced DTH. Through the use of pharmacological inhibition, as well as genetic knockout mice, we found that the induction of MDSCs by AEA was CB1-dependent. The induction of MDSCs by AEA was reduced significantly in mast cell-deficient mice, while maintained in LPS-insensitive mice, showing that the induction of MDSCs by AEA was dependent, at least in part, on mast cells and independent of TLR4. Chemokine analysis of AEA-treated WT mice showed an early spike of MCP-1, which was decreased in Kit(W/W-sh) mice, showing a role of mast cells in the secretion of MCP-1 in response to AEA. Also, use of antibodies against MCP-1 or mice deficient in MCP-1 confirmed the role played by MCP-1. Interestingly, MCP-1 played a significant role in the induction of monocytic but not granulocytic MDSCs. Our studies demonstrate for the first time that endocannaboinids activate CB1 on mast cells to induce MCP-1, which facilitates recruitment of monocytic MDSCs."xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0613350"xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/author | "Jackson A.R."xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/author | "Hegde V.L."xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/author | "Nagarkatti M."xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/author | "Nagarkatti P.S."xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/pages | "609-619"xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/title | "Characterization of endocannabinoid-mediated induction of myeloid-derived suppressor cells involving mast cells and MCP-1."xsd:string |
| http://purl.uniprot.org/citations/24319288 | http://purl.uniprot.org/core/volume | "95"xsd:string |
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