| http://purl.uniprot.org/citations/24322428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24322428 | http://www.w3.org/2000/01/rdf-schema#comment | "By combining in vitro reconstitution biochemistry with a cross-linking approach, we have identified focal segmental glomerulosclerosis 3/CD2-associated protein (FSGS3/CD2AP) as a novel actin barbed-end capping protein responsible for actin stability at the adherens junction. FSGS3/CD2AP colocalizes with E-cadherin and α-actinin-4 at the apical junction in polarized Madin-Darby canine kidney (MDCK) cells. Knockdown of FSGS3/CD2AP compromised actin stability and decreased actin accumulation at the adherens junction. Using a novel apparatus to apply mechanical stress to cell-cell junctions, we showed that knockdown of FSGS3/CD2AP compromised adhesive strength, resulting in tearing between cells and disruption of barrier function. Our results reveal a novel function of FSGS3/CD2AP and a previously unrecognized role of barbed-end capping in junctional actin dynamics. Our study underscores the complexity of actin regulation at cell-cell contacts that involves actin activators, inhibitors, and stabilizers to control adhesive strength, epithelial behavior, and permeability barrier integrity."xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201304143"xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://purl.uniprot.org/core/author | "Brieher W.M."xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://purl.uniprot.org/core/author | "Tang V.W."xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24322428 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://purl.uniprot.org/core/pages | "815-833"xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://purl.uniprot.org/core/title | "FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions."xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://purl.uniprot.org/core/volume | "203"xsd:string |
| http://purl.uniprot.org/citations/24322428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24322428 |
| http://purl.uniprot.org/citations/24322428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24322428 |
| http://purl.uniprot.org/uniprot/#_Q9Y5K6-mappedCitation-24322428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24322428 |
| http://purl.uniprot.org/uniprot/Q9Y5K6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24322428 |