| http://purl.uniprot.org/citations/24324956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24324956 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we aimed to determine the therapeutic effect of allicin on ankylosing spondylitis (AS) and explore the mechanism(s) of action. AS mouse model was constructed by transferring the HLA-B2704 gene into Kunming mice and verified by RT-PCR and CT imaging. Verified AS mice were randomly divided into model group (n = 6) and allicin-treated groups (50, 100, and 200 mg/kg, resp., n = 6, p.o., for 2 months). Wild type mice were used as control (n = 6). The levels of AS-related inflammatory factors were measured by ELISA. mRNA and protein expressions of HLA-B27 were checked by RT-PCR and western blotting. As the results, the mouse model of AS was successfully established, and high-dose allicin could markedly alleviate spine inflammatory injury possibly via reducing the secretion of the inflammatory factors (IL-6, IL-8, and TNF-α ) sharply in AS mice. Moreover, allicin significantly inhibited HLA-B27 protein translation but failed to suppress HLA-B27 gene transcription in AS mice, indicating a posttranscriptional mechanism of this modulation. In conclusion, allicin has potential to be used for AS treatment as an anti-inflammatory nutraceutical."xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.org/dc/terms/identifier | "doi:10.1155/2013/171573"xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/author | "Fu P."xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/pages | "171573"xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/title | "Allicin attenuates inflammation and suppresses HLA-B27 protein expression in ankylosing spondylitis mice."xsd:string |
| http://purl.uniprot.org/citations/24324956 | http://purl.uniprot.org/core/volume | "2013"xsd:string |
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