| http://purl.uniprot.org/citations/24332033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24332033 | http://www.w3.org/2000/01/rdf-schema#comment | "Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies linked pattern-recognition receptor (PRR)-expressing HSCs, EMH, and immune responses to microbial stimuli. However, whether EMH operates in broader immune contexts remains unknown. Here, we demonstrate a previously unrecognized role for thymic stromal lymphopoietin (TSLP) in promoting the population expansion of progenitor cells in the periphery and identify that TSLP-elicited progenitors differentiated into effector cells including macrophages, dendritic cells, and granulocytes and that these cells contributed to type 2 cytokine responses. The frequency of circulating progenitor cells was also increased in allergic patients with a gain-of-function polymorphism in TSLP, suggesting the TSLP-EMH pathway might operate in human disease. These data identify that TSLP-induced EMH contributes to the development of allergic inflammation and indicate that EMH is a conserved mechanism of innate immunity."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2013.09.016"xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Wang M.L."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Hakonarson H."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Comeau M.R."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Kim B.S."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Artis D."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Osborne L.C."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Saenz S.A."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Sleiman P.M."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Spergel J.M."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Farber D.L."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Siracusa M.C."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Benitez A.J."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Cianferoni A."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Wojno E.D."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Ziegler C.G."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/author | "Ruymann K.R."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/pages | "1158-1170"xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/title | "Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation."xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/24332033 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24332033 |