| http://purl.uniprot.org/citations/24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24332809 | http://www.w3.org/2000/01/rdf-schema#comment | "The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor. In response to physiological ER stress, it is processed at the transmembrane region to generate a cytoplasmic N terminus, which contains a basic leucine zipper (bZIP) domain, and luminal C terminus. The BBF2H7 N terminus functions as a transcription factor to promote the expression of ER-Golgi trafficking-related genes and plays crucial roles in chondrocyte differentiation. Here, we found that the BBF2H7 C terminus is secreted into the extracellular space as a signaling molecule for cell-to-cell communication. The secreted BBF2H7 C terminus directly binds to both Indian hedgehog and its receptor Patched-1, followed by activation of Hedgehog signaling, resulting in promoting the proliferation of neighboring chondrocytes. The dual N- and C-terminal functions of BBF2H7 triggered by physiological ER stress may allow chondrocytes to simultaneously regulate distinct cellular events for differentiation and proliferation in developing cartilage."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.11.008"xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/author | "Hino K."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/author | "Saito A."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/author | "Asada R."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/author | "Kanemoto S."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/author | "Imaizumi K."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/pages | "127-139"xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/title | "Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2."xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/24332809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24332809 |
| http://purl.uniprot.org/citations/24332809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24332809 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXF5-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_D4Q8H8-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_D4Q8I4-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPD3-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |
| http://purl.uniprot.org/uniprot/#_A2RRI7-mappedCitation-24332809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24332809 |