| http://purl.uniprot.org/citations/24335996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24335996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24335996 | http://www.w3.org/2000/01/rdf-schema#comment | "Although hypertension is a worldwide health issue, an incomplete understanding of its aetiology has hindered our ability to treat this complex disease. Here we identify arhgap42 (also known as GRAF3) as a Rho-specific GAP expressed specifically in smooth muscle cells (SMCs) in mice and humans. We show that GRAF3-deficient mice exhibit significant hypertension and increased pressor responses to angiotensin II and endothelin-1; these effects are prevented by treatment with the Rho-kinase inhibitor, Y27632. RhoA activity and myosin light chain phosphorylation are elevated in GRAF3-depleted SMCs in vitro and in vivo, and isolated vessel segments from GRAF3-deficient mice show increased contractility. Taken together, our data indicate that GRAF3-mediated inhibition of RhoA activity in vascular SMCs is necessary for maintaining normal blood pressure homoeostasis. Moreover, these findings provide a potential mechanism for a hypertensive locus recently identified within arhgap42 and provide a foundation for the future development of innovative hypertension therapies."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3910"xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3910"xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Bai X."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Bai X."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Taylor J.M."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Taylor J.M."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Rojas M."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Rojas M."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Smithies O."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Smithies O."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Mack C.P."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Mack C.P."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Bird K.E."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Bird K.E."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Kakoki M."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Kakoki M."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Lenhart K.C."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Lenhart K.C."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Suen A.A."xsd:string |
| http://purl.uniprot.org/citations/24335996 | http://purl.uniprot.org/core/author | "Suen A.A."xsd:string |