| http://purl.uniprot.org/citations/24336074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24336074 | http://www.w3.org/2000/01/rdf-schema#comment | "A disintegrin and metalloprotease 17 (ADAM17) is a sheddase with important substrates including tumor necrosis factor-α (TNF-α) and its receptors, the p75 neurotrophin receptor (p75NTR), and members of the epidermal growth factor family. The rationale of this study was to inhibit ADAM17-induced shedding of soluble TNF-α in order to reduce detrimental inflammation after spinal cord injury (SCI). However, using the specific ADAM17 blocker BMS-561392 in neuronal and glial cell cultures, we show that proper functioning of ADAM17 is vital for oligodendrocyte and microglia survival in a p44 MAPK-dependent manner. In contrast, genetic ablation of ADAM17 specifically increases microglial death. Surprisingly, although blocking ADAM17 in vivo does not substantially change the ratio between membrane-bound and soluble TNF-α, it increases expression of the pro-apoptotic marker Bax and microglial apoptosis while impairing functional recovery after SCI. These data suggest that ADAM17 is a key survival factor for microglial cells after SCI."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2013.466"xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/author | "Avila A."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/author | "Hendrix S."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/author | "Chalaris A."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/author | "Lemmens E."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/author | "Vidal P.M."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/author | "Vangansewinkel T."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/pages | "e954"xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/title | "ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice."xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24336074 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24336074 |
| http://purl.uniprot.org/citations/24336074 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24336074 |
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