| http://purl.uniprot.org/citations/24336247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24336247 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypercholesterolemia, typically due to excessive cholesterol uptake, is a major risk factor for cardiovascular disease, which is responsible for ∼50% of all deaths in developed societies. Although it has been shown that intestinal cholesterol absorption is mediated by vesicular endocytosis of the Niemann-Pick C1-like 1 (NPC1L1) protein, the mechanism of sterol-stimulated NPC1L1 internalization is still mysterious. Here, we identified an endocytic peptide signal, YVNXXF (where X stands for any amino acid), in the cytoplasmic C-terminal tail of NPC1L1. Cholesterol binding on the N-terminal domain of NPC1L1 released the YVNXXF-containing region of NPC1L1 from association with the plasma membrane and enabled Numb binding. We also found that Numb, a clathrin adaptor, specifically recognized this motif and recruited clathrin for internalization. Disrupting the NPC1L1-Numb interaction decreased cholesterol uptake. Ablation of Numb in mouse intestine significantly reduced dietary cholesterol absorption and plasma cholesterol level. Together, these data show that Numb is a pivotal protein for intestinal cholesterol absorption and may provide a therapeutic target for hypercholesterolemia."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3417"xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Fu Z.Y."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Zhang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Zhang J.H."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Li B.L."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Li P.S."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Song B.L."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Ma Y.T."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/author | "Xu C.Q."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/pages | "80-86"xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/title | "The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1."xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/24336247 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24336247 |
| http://purl.uniprot.org/citations/24336247 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24336247 |
| http://purl.uniprot.org/uniprot/Q9UHC9#attribution-244DC18390E13A8868AFDA5C98EA19F1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24336247 |
| http://purl.uniprot.org/uniprot/Q9UHC9#attribution-F81ACC3270F0CF0CF31E9820DC80E3D5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24336247 |
| http://purl.uniprot.org/uniprot/#_D3Z7I6-mappedCitation-24336247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24336247 |
| http://purl.uniprot.org/uniprot/#_D3Z7J1-mappedCitation-24336247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24336247 |
| http://purl.uniprot.org/uniprot/#_D3Z1E8-mappedCitation-24336247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24336247 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJJ7-mappedCitation-24336247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24336247 |
| http://purl.uniprot.org/uniprot/#_A3KMG9-mappedCitation-24336247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24336247 |