| http://purl.uniprot.org/citations/24337748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24337748 | http://www.w3.org/2000/01/rdf-schema#comment | "GTPases act as important switches in many signaling events in cells. Although small and heterotrimeric G proteins are subjects of intensive studies, little is known about the large IFN-inducible GTPases. In this article, we show that the IFN-γ-inducible guanylate binding protein 1 (GBP-1) is a regulator of T cell activation. Silencing of GBP-1 leads to enhanced activation of early T cell Ag receptor/CD3 signaling molecules, including Lck, that is translated to higher IL-2 production. Mass spectrometry analyses showed that regulatory cytoskeletal proteins, like plastin-2 that bundles actin fibers and spectrin β-chain, brain 1 that links the plasma membrane to the actin cytoskeleton, are binding partners of GBP-1. The spectrin cytoskeleton influences cell spreading and surface expression of TCR/CD3 and the leukocyte phosphatase CD45. We found higher cell spreading and enhanced surface expression of TCR/CD3 and CD45 in GBP-1 silenced T cells that explain their enhanced TCR/CD3 signaling. We conclude that GBP-1 is a downstream processor of IFN-γ via which T cells regulate cytoskeleton-dependent cell functions."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300377"xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Naschberger E."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Sturzl M."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Forster F."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Stockinger H."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Schmid J.A."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Eckerstorfer P."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Paster W."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Zlabinger G.J."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Schutz G."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Saliba A."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Britzen-Laurent N."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Supper V."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Sunzenauer S."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Ostler N."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/author | "Schatzlmaier P."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/pages | "771-781"xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/title | "Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24337748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24337748 |
| http://purl.uniprot.org/citations/24337748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24337748 |